Sina Curcumin / سینا کورکومین

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SinaCurcumin®

Nano-Micellar Soft gel (80 mg Curcumin)

 

Active Ingredient:

Curcumin, the yellow pigment in curry spice, Turmeric, is the principal curcuminoid in the rhizome of Curcuma longa Linn. The plant is belonging to ginger family (Zingiberaceae) and is native in India and south-east Asia. Curcumin is the prototypical curcuminoid and has effects similar to other polyphenols (diarylheptanoid). In combination with other main curcuminoids including desmethoxycurcumin, bis-desmethoxycurcumin and cyclo-curcumin, they form 3-5% of dried turmeric powder.

Traditional applications:

Turmeric was used in traditional medicine as anti-inflammatory and anti-microbial agent since 5000 years ago. It was used in different diseases such as Rheumatoid Arthritis, Jaundice, Sore throat, Asthma, Allergic conditions, Psoriasis and wound healing.

Pharmacological effects and Indications:

There are more than 3000 studies based on cell culture, animal and clinical, indicating anti-oxidant, anti-inflammation and anti-cancer effect of Curcumin and there is high interest in using Curcumin as supplement in different conditions as:

Anti-inflammatory:

  • Bone and Joint inflammation (Rheumatoid Arthritis, Osteoarthritis) 
  • Gastro-intestinal inflammation (Crown, Gastritis, Colitis, Irritated Bowel Syndrome)
  • Buccal cavity inflammation (Gingivitis, Plague)
  • Dermatological conditions (Psoriasis, Eczema, Wound healing)

Anti-oxidant in prevention different kind of cancers and reducing the adverse effect of chemotherapy and radiation

Supplement in treatment of

  • Depression disorders
  • Cardiovascular problems such as Anti-platelet Aggregation

Anti-lipid Agent

Hepatic disorders and improvement of liver function

Neuropathy and Retinopathy in diabetic patient

Dosage:

One soft gel is containing 80 mg Nano-micellar Curcumin which can be used daily or based on your doctor prescription.

Adverse effect:

Nausea, Vomiting and Diarrhea are the common side effects of Curcumin when used as powder. However, incidence of these conditions using Nano-micellar Curcumin is significantly decreased.

Warning:

Curcumin increases bile secretion. Therefore, prescription is not recommended in patient with gallstone (Colelithiasis).

Pregnancy and Breast-feeding:

There is no study show the effect of the Curcumin in pregnancy and breast-feeding. Therefore it is recommended not to use in this conditions.

Drug interactions:

No documented information is available regarding the drug interaction with Curcumin. However, because of anti-platelet aggregation effect of Curcumin, it may cause bleeding if use with other anti-coagulant agents such as Heparin, Aspirin, Clopidogrel, Dipyridamole, Warfarin, Ticlopidine and NSAIDs like Celecoxib, Diclofenac and Ibuprofen.

Storage Condition:

Less than 25˚C and avoid direct sunlight and moisture.

Advantages of SinaCurcumin:

Curcumin is a lipophilic agent and its absorption from GI with normal dosage forms such as powder, capsules and tablets is very low.

SinaCurcumin is Nano-micellar form of Curcumin in 10 nm average size. The active ingredient, Curcumin, is concentrated inside the micelle which is lipophilic and the hydrophilic part of the micelles increases the solubility in water.

The soft gels of Curcumin are completely dissolve in acidic condition of stomach and the Nano-micelles are released which are stable up to 6 hours in this conditions. The Nano-micelles are delivered to intestine and absorbed there.

 

Articles on Curcumin :

 

Curcumin attenuates severity ofpremenstrual syndrome symptoms:A randomized, double-blind,placebo-controlled trial

 

Curcumin as a potential non-steroidal contraceptive with spermicidal and microbicidal properties.

 

Effect of curcumin on serum brain-derived neurotrophic factor levels in women with premenstrual syndrome: A randomized, double-blind, placebo-controlled trial