Sinanomin / سینانومین

 

Sinanomin®

 

Dosage form:

Topical gel contains %1 curcumin as nanoliposome (active ingredient of rhizome of Curcuma longa)

Active ingredient:

Curcumin (Diferuloylmethane), a polyphenol from the diarylheptanoids group, is the principal curcuminoid of turmeric, known as Curcuma longa belonging to the Zinger family. In combination with other main curcuminoids including desmethoxycurcumin, bis-desmethoxycurcumin, they form 3-5% of dried turmeric powder.

Pharmacological effects and Indications:

The rhizome of Curcuma longa has been used as a healer agent in the form of salve and ointment traditionally. It has been also used for bacterial and fungous infections such as tinea topically. Nowadays it is proved that these extra effects are related to antioxidant; anti-inflammatory, anti-microbial and anti-fungal effects of curcuminoids in curcuma longa rhizomes.

Topical Gel of Sinanomin:

Used as improver of inflammation, pain and wound in dermatological conditions due to burn, insect bites, injury and diabetic neuropathy.

It´s useful for skin sensitivity and inflammatory diseases such as itching, burning, Eczema, Psoriasis and Acne.

It is effective in relieving muscle and joint pain.

It is effective for alleviating of Gingivitis and Aphthous.

 

Mechanism of action:

The anti-inflammatory effect of curcumin is most likely mediated through its ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS). COX-2, LOX, and iNOS are important enzymes that mediate inflammatory processes. 

Curcumin has an important role in acceleration of wound healing and prevention of scar through inhibiting phosphorylase kinase enzyme and NFkB and TGFB with preventing reproduction of fibroblasts and decreasing inflammatory reactions.

Advantages of Nanoliposomal gel of curcumin:

Curcumin is insoluble in water which restrics usage of curcumin in the form of topical.

Encapsulation of curcumin in liposomal nanoparticles has solved this problem. Furthermore it can increase permeability and skin absorption of curcumin snd its resistance versus decomposition due to the light , too.

This product isn’t greasy and is washable with water.

 

Necessary information before using this medicine:

  • Read entire leaflet carefully before you start your treatment with this medicine.
  • If you have any further questions, consult with your doctor or pharmacist.
  • If you are sensitive to turmeric and other substance of gel, don’t use this product.
  • Your skin becomes yellow temporary after using.
  • Test this gel on the small part of your arm or behind the auricle before first consumption and if you haven’t any sensitivity, use it according to instructions.
  • Don’t use this product in your eyes.

Proper use of this medicine:

Apply enough Sinanomin gel in a thin layer three times a day on clean skin and damaged areas. It is best to use with cotton in damaged areas.

You can use more times if needed.

Don’t wash the affected areas up to 2 hours after the application of sinanomin gel.

Side effects:

It isn’t reported any side effects until now.

 

References:

  1. T Akbik D, et al, Curcumin as a wound healing agent, Life Sci (2014),hangapazham R, Sharad S, Maheshwari R. Skin regenerative potentials of curcumin. Biofactors 2013;39:141–9.
  2. Mohanty C, Das M, Sahoo S. Sustained wound healing activity of curcumin loaded oleic acid based polymeric bandage in a rat model. Mol Pharm 2012;9:2801–11.
  3. Merrell JG, McLaughlin SW, Tie L, Laurencin CT, Chen AF, Nair LS. Curcumin-loaded poly(epsilon-caprolactone) nanofibres: diabetic wound dressing with anti-oxidant and anti-inflammatory properties. Clin Exp Pharmacol Physiol 2009;36:1149–56.
  4. KulacM, Aktas C, Tulubas F, Uygur R, KanterM, ErbogaM, et al. The effects of topical treat-ment with curcumin on burn wound healing in rats. J Mol Histol 2013;44:83–90.
  5. Gadekar R, Saurabh M, Thakur G, Saurabh A. Study of formulation, characterisation and wound healing potential of transdermal patches of curcumin. Asian J Pharm Clin Res 2012;5:225–30.
  6. Hegge A, Andersen T, Melvik J, Bruzell E, Kristensen S, Tonnesen H. Formulation and bacterial phototoxicity of curcumin loaded alginate foams for wound treatment applications: studies on curcumin and curcuminoides XLII. J Pharm Sci 2011;100:174–85.
  7. Panahi, Y., Sahebkar, A., Amiri, M., Davoudi, S. M., Beiraghdar, F., Hoseininejad,S. L., and Kolivand, M. (2011) Improvement of sulphur mustardinducedchronic pruritus, quality of life and antioxidant status by curcumin:results of a randomised, double-blind, placebo-controlled trial. Br. J.Nutr. 108, 1272–1279.
  8. Gopinath D, Ahmed MR, Gomathi K, ChitraK,Sehgal PK, Jayakumar R (2004), Dermal wound healing processes with curcumin incorporated collagen films. Biomaterials 25; 1911-1917.
  9. Muglikar S, Patil KC, Shivswami S, Hegde R. Efficacy of curcumin in the treatment of chronic gingivitis: a pilot study. (2013) Oral Health Prev Dent .:11(1):81-6.
  10. Manifar S, Obwaller A, Gharehgozloo A, Boorboor Shirazi Kordi HR, Akhondzadeh S, (2012), Curcumin Gel in the Treatment of Minor Aphthous Ulcer: a Randomized, Placebo- Controlled Trial Journal of Medicinal Plants,11 (41): 40-45.
  11. Krausz AE, Adler BL, Cabral V, Navati M, Doerner J, Charafeddine RA, Chandra D, Liang H, Gunther L, Clendaniel A, Harper S, Friedman JM, Nosanchuk JD, Friedman AJ. (2015 Jan) Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomedicine. 11(1):195-206.
  12. Dania Akbik, Maliheh Ghadiri, Wojciech Chrzanowski, Ramin Rohanizadeh (22 October 2014), Curcumin as a wound healing agent, Life Sciences, 116 (1): 1-7.
  13. Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest. 2007;117(5):1219-22. Epub 2007/05/04.